Characterization of the significant decline in humoral immune reaction six month post-SARS-CoV-2 mRNA vaccination : A systematic review

Characterization of the significant decline in humoral immune reaction six month post-SARS-CoV-2 mRNA vaccination : A systematic review

Affiliations

  • 1Faculty of Medicine and Surgery , University of Santo Tomas , Manila , Philippines .
  • 2Disease Intervention & Prevention and Population Health Programs , Texas Biomedical Research Institute , San Antonio , Texas , USA .
  • 3Department of Biostatistics , State University of Maringa , Maringá , Brazil .
  • 4Department of Public Health , Medical University of Warsaw , Warsaw , Poland .
  • 5Section of Clinical Biochemistry , University of Verona , Verona , Italy .

  • PMID :
    35229324

  • PMCID :PMC9088566

  • DOI :10.1002/jmv.27688

Characterization of the important decline in humoral immune reception six months post-SARS-CoV-2 mRNA vaccination : A systematic review

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Writer

Affiliations

  • 1Faculty of Medicine and Surgery , University of Santo Tomas , Manila , Philippines .
  • 2Disease Intervention & Prevention and Population Health Programs , Texas Biomedical Research Institute , San Antonio , Texas , USA .
  • 3Department of Biostatistics , State University of Maringa , Maringá , Brazil .
  • 4Department of Public Health , Medical University of Warsaw , Warsaw , Poland .
  • 5Section of Clinical Biochemistry , University of Verona , Verona , Italy .

  • PMID :
    35229324

  • PMCID :PMC9088566

  • DOI :10.1002/jmv.27688

Abstraction

Accumulating evidence present a progressive decline in the efficacy of coronavirus disease 2019 ( COVID-19 ) ( severe acute respiratory syndrome coronavirus 2 [ SARS-CoV-2 ] ) messenger RNA ( mRNA ) vaccines such as Pfizer-BioNTech ( mRNA BNT161b2 ) and Moderna ( mRNA-1273 ) in prevent discovery infections due to diminishing humoral immunity over time . Hence , this review characterize the kinetics of anti-SARS-CoV-2 antibodies after the second dosage of a main cycle of COVID-19 mRNA vaccination . A systematic search of the literature be performed and a total of 18 articles ( N = 15 980 participants ) were identified and go over . The percent dispute of mean of cover antibody titers equal then estimate to find out the decline in humoral reply after the height levels postvaccination . Findings reveal that the peak humoral response exist reach at 21-28 day after the second dose , after which serum level increasingly decrease at 4-6-month postvaccination . Additionally , results showed that regardless of years , sex , serostatus , and presence of comorbidities , longitudinal data report antibody measurement demonstrate a decline of both anti-receptor binding domain immunoglobulin G ( IgG ) and anti-spike IgG , wander from 94 % to 95 % at 90-180 day and 55 % -85 % at 140-160 days , respectively , after the point antibody reception . This suggest that the pace of antibody decline may be sovereign of patient-related factor and peak antibody titer but mainly a occasion of time and antibody class/molecular target . Hence , this study highlights the requirement of more efficient vaccination strategy to provide booster administration in attenuating the effects of go down immunity , specially in the appearance of new discrepancy of concerns .

Keywords :COVID-19 ; Moderna ; Pfizer-BioNTech ; mRNA 1273 ; mRNA BNT162b2 ; vaccines .

Conflict of interest argument

Figure

Shield and assessment of diary article for inclusion in the systematic review

Kinetics of antibodies in studies reporting longitudinal data indicate percentage decline from peak…

Comparison by years of the percentage decline of anti‐SARS‐CoV‐2 antibodies by immunoglobulin class…

Comparison by sex of the percent decline of anti‐SARS‐CoV‐2 antibodies by immunoglobulin class…

Comparison of antibody levels of seronegative and seropositive kinetics in field report longitudinal…

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